FIG. 7.

Inhibition of JNK activity rescued the viability of cells infected with pUL38-deficient virus. HFs were infected with ADwt or ADpmUL38 at an MOI of 3 in the presence of the JNK inhibitor SP600125 at 0, 25, or 50 μM; cell survival at 72 and 96 h was measured by trypan blue exclusion assay (A), and caspase 3, PARP, JNK, and ATF4 at 72 h were examined by immunoblotting (B). Cell viability was normalized to that at the time of infection.