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. 2009 Feb 2;29(8):2193–2204. doi: 10.1128/MCB.01222-08

FIG. 6.

FIG. 6.

miR-1 negatively regulates NFAT signaling. (A) miR-1 overexpression inhibited NFAT-luciferase activity. NRVMs were treated with adenovirus containing an NFAT-dependent luciferase reporter and with the indicated miRNA-expressing adenoviruses. Levels of NFAT activity were increased by ET-1 and were decreased by miR-1 overexpression. *, P < 0.01 versus empty vector. (B) miR-1 knockdown increased NFAT-luciferase activity. NRVMs were treated NFAT-luciferase adenovirus and miR-1 or unrelated antagomir (GFP). *, P < 0.05 (n = 3). PBS, phosphate-buffered saline.