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. 2009 Feb 17;29(8):2129–2138. doi: 10.1128/MCB.01644-08

FIG. 5.

FIG. 5.

Pancreatic histology and β-cell function in adult MFng−/− pancreas are normal. (A to E′) Immunohistochemical analysis of the endocrine hormones insulin, glucagon, somatostatin, and PP (as indicated in panels A to B′), the endocrine markers Ipf1 and Isl1 (red in panels C to D′), the vasculature markers pecam and smooth muscle actin (s.m.ac.; green in panels C, C′, E, and E′), the duct marker DBA (green in panels D and D′), and the exocrine enzyme amylase (red in panels E and E′) in pancreases of MFng+/− (A to E) and MFng −/− (A′ to E′) mice. Nuclear staining with DAPI (4′,6-diamidino-2-phenylindole; blue) is shown in panels E and E′. (F) The patterns of the clearance of glucose from the blood after the intraperitoneal (i.p.) injection of MFng+/− (n = 13) and MFng−/− (n = 8) mice with glucose were similar. Values are shown with SEM.