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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Nat Chem Biol. 2009 Jan 15;5(2):82–90. doi: 10.1038/nchembio.139

Figure 3. Ubiquitin conjugation pathway and enzymes involved in PCNA ubiquitination.

Figure 3

Cartoon depiction of the ubiquitin conjugation pathway. Ubiquitination occurs through at least three concerted reactions. Enzymes responsible for mono- and polyubiquitination of PCNA are as indicated. Human homologs of yeast Rad5 are in parenthesis. E1 = ubiquitin activating enzyme (yellow). E2 = ubiquitin conjugating enzyme (green). E3 = ubiquitin ligase (red). DUB = deubiquitinating enzyme (orange). Ub = ubiquitin. Substrate is shown in purple.