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. Author manuscript; available in PMC: 2009 Aug 1.

Published in final edited form as: Nat Biotechnol. 2009 Feb 1;27(2):182–189. doi: 10.1038/nbt.1523

Normalized coverage-distribution plots. Shown is the fraction of bait-covered bases in the genome achieving coverage with uniquely aligned sequence equal or greater than the normalized coverage indicated on the X-axis. The absolute per base coverage was divided by the mean coverage of all bait positions (18 in a; 221 in b). The curve for the shotgun-sequenced exon capture (a) is steeper than the curve for the regional capture (b) indicating a less uniform representation of sequencing targets in the exon catch. Dashed lines point to the fraction of bases achieving at least half or one fifth the mean coverage.

Normalized coverage-distribution plots. Shown is the fraction of bait-covered bases in the genome achieving coverage with uniquely aligned sequence equal or greater than the normalized coverage indicated on the X-axis. The absolute per base coverage was divided by the mean coverage of all bait positions (18 in a; 221 in b). The curve for the shotgun-sequenced exon capture (a) is steeper than the curve for the regional capture (b) indicating a less uniform representation of sequencing targets in the exon catch. Dashed lines point to the fraction of bases achieving at least half or one fifth the mean coverage.