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. Author manuscript; available in PMC: 2009 Mar 31.
Published in final edited form as: Circulation. 2007 Dec 24;117(3):379–387. doi: 10.1161/CIRCULATIONAHA.107.741181

Figure 1. 64Cu-TNP.

Figure 1

Schematic view of tri-modality reporter 64Cu-TNP.

1A: Derivatization with chelator DTPA allows attachment of radiotracer 64Cu.

1B: Iron oxide core provides contrast in magnetic resonance imaging (T2, T2* or SSFP sequences).

1C: Fluorochrome VT680 for fluorescence imaging including fluorescence microscopy, flow cytometry, and fluorescence mediated tomography.

1D: Crosslinked aminated polysaccharide coating provides biocompatibility, determines blood half-life and provides linker for attachment of tracers, and potentially affinity ligands.