Schematic view of tri-modality reporter 64Cu-TNP.
1A: Derivatization with chelator DTPA allows attachment of radiotracer 64Cu.
1B: Iron oxide core provides contrast in magnetic resonance imaging (T2, T2* or SSFP sequences).
1C: Fluorochrome VT680 for fluorescence imaging including fluorescence microscopy, flow cytometry, and fluorescence mediated tomography.
1D: Crosslinked aminated polysaccharide coating provides biocompatibility, determines blood half-life and provides linker for attachment of tracers, and potentially affinity ligands.