Table 4.

Plasma concentrations of hemostatic endothelial cell markers in diabetic patients with and without vascular complications compared with control subjects (means ± SD)

	Controls	Diabetics
	(n = 38)	without complications n = 27)	with complications n = 27)
PAI-1 (ng/mL)	13.7 ± 7.5	51.1 ± 37b	50.0 ± 40.4b
tPA (ng/mL)	6.2 ± 4.1	10.9 ± 4.4b	10.5 ± 4.4b
vWF (IU/dL)	136 ± 48	145 ± 50	180 ± 65bc
f-TFPI (ng/mL)	7.6 ± 3.9	7.8 ± 2.5	9.6 ± 2.5ac
s-TM (ng/mL)	56.8 ± 30.5	53.4 ± 16	77.1 ± 46.7ac

Statistical analysis: one way parametric ANOVA except for PAI-1 (Kruskall Wallis non parametric ANOVA)

^ap < 0.05 vs controls;

^bp < 0.01 vs controls;

^cp < 0.05 vs diabetics without complications.

Abbreviations: PAI-1, plasminogen activator inhibitor-1; vWF, von Willebrand factor; tPA, tissue plasminogen activator; f-TFPI, free tissue pathway factor inhibitor; s-TM, soluble form of thrombomodulin.