Comparison of Gene Frequencies based on Carrier Freqs (assuming HWP) and Segregation Analysis in unrelated CEPH individuals

locus	Carrier Frequency	Gene Frequency assuming HWP (a)	Gene Frequency by Segregation Analysis	difference	% difference
K3DL3	1.000	1.000	1.000	0.000	0.0%
K2DS2	0.607	0.373	0.354	0.019	5.4%
K2DL2	0.584	0.355	0.343	0.013	3.7%
K2DL3	0.888	0.665	0.640	0.024	3.8%
K2DL5B	0.247	0.132	0.140	-0.008	-5.8%
K2DP1	0.966	0.816	0.781	0.036	4.5%
K2DL1	0.966	0.816	0.781	0.036	4.5%
K3DP1	1.000	1.000	0.994	0.006	0.6%
K2DL4	1.000	1.000	0.989	0.011	1.1%
K3DL1	0.944	0.763	0.770	-0.007	-0.9%
K3DS1	0.393	0.221	0.225	-0.004	-1.6%
K2DL5A	0.371	0.207	0.213	-0.007	-3.1%
K2DS3	0.292	0.159	0.174	-0.016	-8.9%
K2DS5	0.303	0.165	0.163	0.002	1.5%
K2DS1	0.393	0.221	0.225	-0.004	-1.6%
K2DS4	0.944	0.763	0.775	-0.012	-1.6%
K3DL2	1.000	1.000	1.000	0.000	0.0%

^(a)GF=1 - sqrt(1 - CF)

A comparison of gene frequencies (GF) estimated from carrier frequencies (CF), and the assumption of HWP, with gene frequency results from segregation analysis in the CEPH samples. Gene frequencies were estimated by gene counting based on the segregation analysis results and also by applying Bernstein's formula to the carrier frequencies for the KIR genotypes from presence/absence data.