Correlation between KIR and HLA ligand frequencies.

locus pair	Correlation(a)	p-value(b) (Pearson)	p-value(c) (empirical)	p-value(d) (permutation)
3DS1 - Bw4	-0.632	<0.001	0.041	0.012
3DS1 - Bw480i	-0.657	<0.001	0.038	0.009
3DS1 - Bw480t	-0.19	0.316	0.534	0.532
3DL1 - Bw4	0.426	0.019	0.218	0.106
3DL1 - Bw480i	0.416	0.022	0.191	0.115
3DL1 - Bw480t	0.171	0.367	0.758	0.54
2DL1 - C group2	0.046	0.81	0.924	0.891
2DL2 - C group1	-0.366	0.047	0.542	0.193
2DL3 - C group1	0.184	0.331	0.328	0.458
2DS1 - C group2	-0.478	0.008	0.149	0.243
2DS2 - C group1	-0.371	0.044	0.479	0.17

^(a)Pearson product-moment correlation between KIR carrier frequency (CF) and HLA ligand gene frequency (GF).

^(b)The ordinary Pearson product-moment correlation p-value, which does not account for non-independence among populations.

^(c)The empirical p-value is the proportion of times that a larger absolute correlation than the true correlation between KIR GF and HLA GF was observed in the empirical distribution, generated by computing correlations between GFs for 10,000 pairs of unlinked sites typed in the same populations as the present study from the ALFRED database.

^(d)The resampling p-value is the proportion of times that a larger absolute correlation than the true correlation between KIR CF and HLA GF was observed in the resampling distribution, generated by computing correlations between KIR CF and “reassigned HLA” GF 10,000 times.