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Cancellous bone tissue in the lumbar vertebral body of an aged OVX rat treated for 3 weeks with the EP4 agonist, which induced formation of large, multinucleated osteoclasts (arrow) within resorptive lacunae. EP4 treatment increased osteoclast surface, an index of bone resorption, by nearly three-fold compared with baseline OVX rats. (Von Kossa/tetrachrome stain; original magnification, X400).
