Table 3.
Comparison of parameter values for human and MDCK cells in a hollow-fiber system
| Parameters | |||||||
|---|---|---|---|---|---|---|---|
| System | Model | tEa | (95% CI) | 1/δb | (95% CI) | R0c | (95% CI) |
| Human d | simple | — | — | 6.0 h | (3.9–9.2 h) | 11 | (6.6–19) |
| eclipse | 6.0 h | (4.6–7.9 h) | 4.6 h | (2.8–7.5 h) | 22 | (10–46) | |
| HFe | simple | — | — | 13 h | (11–16 h) | 11 | (7.5–19) |
| eclipse | 3.2 h | (0.041–12 h) | 13 h | (6.9–16 h) | 36 | (10–120) | |
| delay | 0.22 h | (0.0028–1.3 h) | 13 h | (11–16 h) | 13 h | (9.5–25) | |
a
Length of the eclipse phase where tE = 1/k (eclipse) or τ (delay).
b
Length of time over which infected cells produce virions.
c
Basic reproductive number.
d
Averaged results for infection of 6 human volunteers with inuenza A/HK/123/77 (H1N1) from Baccam et al. (2006).
e
Results from the hollow-fiber (HF) system as per Table 2.