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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Cardiovasc Drugs Ther. 2008 Oct 24;23(1):41–48. doi: 10.1007/s10557-008-6140-9

Fig. 1.

Fig. 1

The formation of leukotrienes (LTs) through the 5-lipoxygenase pathway of arachidonic acid metabolism, and the effects of LT inhibitors in different contexts. Gray ovals indicate the enzymes involved in LT biosynthesis; Phospholipase A2 (PLA2), 5-lipoxygenase (5-LO) with its activating protein (FLAP), LTA4 hydrolase (LTA4H), and LTC4 synthase (LTC4S). Rectangles indicate the LT receptors. Examples of LT synthesis inhibitors are indicated by black triangles, whereas examples of LT receptor antagonists are indicated by open triangles