Table 2.
Serum levels of IGF-I, betaFGF and VEGF in Control, MGUS and MM
| Group | N° | IGF-I ng/ml |
B-FGF pg/ml |
VEGF pg/ml |
| Controls | 55 | 135.5 (65–279) |
1.62 (1.04–2.15) |
1.25 (0.15–1.95) |
| MGUS | 71 | 111.3 (10–215.8) |
2.08 (0.04–8.19) |
1.12 (0.15–5.90) |
| MM | 77 | 78 (16–352) |
2.37 (0.04–82.7) |
1.37 (0.3–18.3) |
| P1 | <.0001 | 0.01 | 0.19 | |
| P2 | -- | <.0001 | .001 | .57 |
| P3 | -- | <.0001 | .27 | .14 |
| P4 | -- | <.0001 | .02 | .14 |
A statistical analysis has been performed both on the three groups together and on the different couple of groups.
Cytokine levels are given as median (range). P1 = univariate analysis, Kruskall-Wallis test on the three groups. P2 = univariate analysis, Mann Whitney test on Controls vs MGUS. P3 = univariate analysis, Mann Whitney test on MGUS vs MM. P4 = univariate analysis, Mann Whitney test on Controls vs MM.
The IGF-I behaviour has been also confirmed by logistic regression analysis after data correction for age and gender, as described in the text.