Table 3.
WREMB-R evening and morning subscores and GIPD single item scores (mean ± SD, LOCF).
| Baseline (BL) | Week 2 | Week 8 | Week 24 | ||||||||
| N | Score | N | Score | Change | N | Score | Change | N | Score | Change | |
| WREMB-R | |||||||||||
| Evening subscore (8 items) |
418 | 13.7 ± 5.24 | 419 | 8.0 ± 5.57 | -5.7 ± 5.43 | 419 | 7.1 ± 5.78 | -6.6 ± 6.14 | 419 | 8.0 ± 6.16 | -5.7 ± 6.30 |
| Morning subscore (3 items) |
419 | 4.3 ± 2.49 | 418 | 2.4 ± 2.23 | -1.8 ± 2.53 | 419 | 2.1 ± 2.22 | -2.2 ± 2.84 | 419 | 2.3 ± 2.37 | -1.9 ± 2.83 |
| GIPD | |||||||||||
| Difficulties in the morning | |||||||||||
| patient-rated | 418 | 2.5 ± 1.60 | 418 | 2.0 ± 1.40 | -0.5 ± 1.74 | 419 | 1.9 ± 1.35 | -0.6 ± 1.80 | 419 | 1.9 ± 1.40 | -0.6 ± 1.68 |
| parent-rateda | 418 | 3.4 ± 1.69 | 393 | 2.5 ± 1.44 | -0.9 ± 1.77 | 404 | 2.4 ± 1.55 | -1.0 ± 1.97 | 409 | 2.5 ± 1.62 | -0.9 ± 1.97 |
| physician-rated | 419 | 3.6 ± 1.58 | 419 | 2.5 ± 1.33 | -1.1 ± 1.71 | 419 | 2.3 ± 1.45 | -1.3 ± 1.84 | 419 | 2.6 ± 1.57 | -1.1 ± 1.82 |
| Difficulties during school | |||||||||||
| patient-rated | 417 | 2.7 ± 1.65 | 417 | 2.1 ± 1.34 | -0.6 ± 1.66 | 418 | 2.1 ± 1.52 | -0.6 ± 1.93 | 418 | 2.2 ± 1.60 | -0.5 ± 2.04 |
| parent-rateda | 415 | 3.6 ± 1.58 | 389 | 2.9 ± 1.48 | -0.8 ± 1.75 | 403 | 2.8 ± 1.61 | -0.9 ± 1.96 | 408 | 3.0 ± 1.73 | -0.7 ± 2.11 |
| physician-rated | 416 | 4.0 ± 1.51 | 419 | 2.9 ± 1.40 | -1.1 ± 1.77 | 419 | 2.7 ± 1.60 | -1.3 ± 2.00 | 419 | 3.0 ± 1.75 | -1.0 ± 2.12 |
| Difficulties during homework | |||||||||||
| patient-rated | 416 | 2.7 ± 1.67 | 417 | 2.2 ± 1.51 | -0.5 ± 1.81 | 418 | 2.1 ± 1.50 | -0.6 ± 1.91 | 418 | 2.2 ± 1.59 | -0.5 ± 1.93 |
| parent-rateda | 417 | 4.0 ± 1.65 | 390 | 3.1 ± 1.51 | -1.0 ± 1.67 | 403 | 3.0 ± 1.63 | -1.0 ± 1.97 | 408 | 3.0 ± 1.69 | -1.0 ± 2.03 |
| physician-rated | 415 | 4.2 ± 1.56 | 418 | 3.0 ± 1.46 | -1.2 ± 1.72 | 419 | 2.9 ± 1.62 | -1.4 ± 1.91 | 419 | 3.0 ± 1.68 | -1.2 ± 1.99 |
| Difficulties in the evening | |||||||||||
| patient-rated | 418 | 2.5 ± 1.72 | 419 | 1.9 ± 1.26 | -0.6 ± 1.67 | 419 | 1.9 ± 1.32 | -0.6 ± 1.86 | 419 | 1.9 ± 1.34 | -0.6 ± 1.84 |
| parent-rateda | 419 | 3.8 ± 1.60 | 394 | 2.8 ± 1.50 | -1.0 ± 1.66 | 404 | 2.6 ± 1.52 | -1.2 ± 1.79 | 409 | 2.7 ± 1.60 | -1.1 ± 1.87 |
| physician-rated | 419 | 4.2 ± 1.47 | 419 | 2.8 ± 1.43 | -1.4 ± 1.56 | 419 | 2.6 ± 1.54 | -1.5 ± 1.82 | 419 | 2.9 ± 1.72 | -1.3 ± 1.85 |
Change is shown relative to baseline.
BL = baseline, GIPD = Global Impression of Perceived Difficulties, LOCF = last patient carried forward analysis, N = Number of patients, SD = standard deviation, WREMB-R = Weekly Ratings of Evening and Morning Behavior-Revised.
a Post-baseline parent-rated GIPD scores were considered only if rated by the baseline rater.