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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Stroke. 2009 Feb 10;40(4):1169–1175. doi: 10.1161/STROKEAHA.108.527788

Figure 3. Anticonvulsant Activity of Magnesium Sulfate.

Figure 3

Seizures consist of an excessive release of excitotoxic neurotransmitters including glutamate. Excessive glutamate can activate the N-methyl-d-aspartate (NMDA) receptor, leading to massive depolarization of neuronal networks and bursts of action potentials. Magnesium may act to increase the seizure threshold by inhibiting NMDA receptors, thereby limiting the effect of glutamate.