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Vascular Effects of Magnesium Sulfate.
| Cellular Target | Mode of Action | Possible Mechanism(s) |
|---|---|---|
|
Smooth Muscle Uterine +++ Mesenteric +++ Aorta +++ Cerebral + |
Relaxation ↓ Vasodilation ↓ Decreased Vascular Resistance |
Calcium Antagonism Decreased Voltage-operated Calcium Channel (VOCC) Activity Decreased [Ca+2]i Release From Sarcoplasmic Reticulum |
| Endothelium | Decreased Platelet Aggregation | Increased Prostaglandin I2 (PGI2) |
| Vasodilation | Increased Nitric Oxide (NO, Gestation Dependent) |
|
