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Effect of Magnesium Sulfate on Cerebral Edema and the Blood-brain Barrier.
| Cellular Target | Mode of Action | Possible Mechanism |
|---|---|---|
|
Cerebral Endothelium |
Decreased Blood-brain Barrier (BBB) disruption ↓ Limited Cerebral Edema Formation Via Paracellular Transport |
Calcium Antagonism ↓ Decreased Cell Contraction ↓ Decreased Tight Junction Permeability |
| Limited Transcellular Transport | Decreased Pinocytosis | |
| Astrocyte | Limited Cerebral Edema | Decreased Aquaporin 4 (AQP4) Expression |
