Table 2.
Hazard ratios (HRs) of total stroke according to quintiles of body mass index, waist-hip ratio, waist circumference, and waist-height ratio
| Quintiles of anthropometric measures |
||||||
|---|---|---|---|---|---|---|
| Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Quintile 5 | P for trend | |
| Body mass index, kg/m2 | ||||||
| Quintile cutoffs | <21.1 | 21.1–22.7 | 22.8–24.3 | 24.4–26.5 | ≥26.6 | |
| No. of subjects | 13420 | 13391 | 13514 | 13341 | 13417 | |
| No. of cases | 269 | 320 | 403 | 584 | 827 | |
| Age-adjusted HR | 1.00 | 1.16 (0.99–1.36) | 1.26 (1.08–1.47) | 1.56 (1.35–1.81) | 1.82 (1.59–2.10) | < 0.0001 |
| Multivariate HR* | 1.00 | 1.16 (0.98–1.36) | 1.24 (1.06–1.45) | 1.51 (1.30–1.74) | 1.71 (1.49–1.97) | < 0.0001 |
| Additionally adjusted for WHR | 1.00 | 1.10 (0.93–1.29) | 1.15 (0.98–1.34) | 1.37 (1.17–1.59) | 1.53 (1.32–1.78) | < 0.0001 |
| Additionally adjusted for WC | 1.00 | 1.08 (0.91–1.30) | 1.08 (0.89–1.30) | 1.20 (0.99–1.47) | 1.24 (1.01–1.53) | 0.03 |
| Additionally adjusted for WHtR | 1.00 | 1.01 (0.85–1.22) | 0.97 (0.80–1.17) | 1.06 (0.87–1.30) | 1.10 (0.89–1.36) | 0.17 |
| Waist-hip ratio, cm/cm | ||||||
| Quintile cutoffs | <0.77 | 0.77–0.78 | 0.79–0.81 | 0.82–0.84 | ≥0.85 | |
| No. of subjects | 13430 | 13495 | 13319 | 13345 | 13494 | |
| No. of cases | 231 | 322 | 416 | 576 | 858 | |
| Age-adjusted HR | 1.00 | 1.22 (1.03–1.45) | 1.33 (1.13–1.56) | 1.56 (1.34–1.82) | 1.71 (1.48–1.98) | < 0.0001 |
| Multivariate HR* | 1.00 | 1.21 (1.02–1.43) | 1.29 (1.10–1.52) | 1.49 (1.28–1.74) | 1.59 (1.37–1.85) | < 0.0001 |
| Additionally adjusted for BMI | 1.00 | 1.15 (0.97–1.36) | 1.18 (1.00–1.39) | 1.32 (1.12–1.55) | 1.34 (1.15–1.57) | < 0.0001 |
| Waist circumference, cm | ||||||
| Quintile cutoffs | <70.1 | 70.1–75.0 | 75.1–79.0 | 79.1–84.0 | ≥84.1 | |
| No. of subjects | 14941 | 14755 | 11482 | 12590 | 13315 | |
| No. of cases | 237 | 311 | 336 | 549 | 970 | |
| Age-adjusted HR | 1.00 | 1.09 (0.92–1.29) | 1.24 (1.05–1.47) | 1.48 (1.27–1.73) | 1.90 (1.64–2.19) | < 0.0001 |
| Multivariate HR* | 1.00 | 1.09 (0.92–1.30) | 1.23 (1.04–1.45) | 1.43 (1.22–1.67) | 1.77 (1.53–2.05) | < 0.0001 |
| Additionally adjusted for BMI | 1.00 | 1.04 (0.87–1.26) | 1.13 (0.92–1.38) | 1.26 (1.03–1.55) | 1.50 (1.21–1.86) | < 0.0001 |
| Waist-height ratio, cm/cm | ||||||
| Quintile cutoffs | <0.44 | 0.44–0.46 | 0.47–0.49 | 0.50–0.53 | ≥0.54 | |
| No. of subjects | 13404 | 13411 | 13642 | 13205 | 13421 | |
| No. of cases | 163 | 220 | 363 | 581 | 1076 | |
| Age-adjusted HR | 1.00 | 1.05 (0.86–1.28) | 1.30 (1.08–1.57) | 1.62 (1.36–1.94) | 2.07 (1.75–2.46) | < 0.0001 |
| Multivariate HR* | 1.00 | 1.05 (0.86–1.28) | 1.27 (1.06–1.53) | 1.55 (1.30–1.85) | 1.91 (1.61–2.27) | < 0.0001 |
| Additionally adjusted for BMI | 1.00 | 1.05 (0.84–1.30) | 1.26 (1.01–1.57) | 1.50 (1.19–1.89) | 1.77 (1.38–2.26) | < 0.0001 |
*
Adjusted for age, education, occupation, family income, menopausal status, use of oral contraceptives, hormone therapy, and aspirin, amount of exercise, cigarette smoking, alcohol consumption, and intakes of saturated fat, vegetables, fruits, and sodium.