Table I.
Composition of Different Microparticular Systems Containing Indinavir Sulfate Obtained by a Double Emulsion/Solvent Evaporation Method
| Formulation | Type of emulsion | Theoretical indinavir sulfate monoethanolate loading (wt.%) | Theoretical indinavir free base loading (wt.%) | Experimental indinavir free base loading (wt.%) ± SD | % f load ± SD |
|---|---|---|---|---|---|
| MP20Aa | w/o/w | 20 | 16.2 | 10.9 ± 0.4 | 67.3 ± 2.5 |
| MP20 | w/o/o | 20 | 16.2 | 15.2 ± 0.8 | 91.3 ± 5.2 |
| MP40 | w/o/o | 40 | 32.4 | 30.1 ± 1.2 | 92.8 ± 1.2 |
| MP60 | w/o/o | 60 | 48.6 | 43.6 ± 1.5 | 89.8 ± 3.1 |
MP microparticular
aMP20A denotes preliminary microparticles prepared by a w/o/w technique. The procedure was modified in order to improve the levels of % f load