Table I.
Composition and Characterization of the Films
| Film code | Ratio of ERL/EC (%, w/w) | AZT (%, w/w) | DBS (%, w/w) | Thickness (μm) | AZT amount (μg/cm2) |
|---|---|---|---|---|---|
| F1 | 100:0 | 2.5 | 25 | 293 ± 1.5 | 632.5 ± 6.7 |
| F2 | 80:20 | 2.5 | 25 | 307 ± 2.0 | 628.6 ± 20.1 |
| F3 | 60:40 | 2.5 | 25 | 313 ± 2.0 | 656.1 ± 13.7 |
| F4 | 50:50 | 2.5 | 25 | 317 ± 2.6 | 686.5 ± 9.9 |
| F5 | 0:100 | 2.5 | 25 | 327 ± 3.4 | 473.0 ± 43.9 |
| F6 | 100:0 | 5.0 | 25 | 297 ± 1.9 | 1475.8 ± 28.5 |
| F7 | 50:50 | 5.0 | 25 | 322 ± 1.2 | 1401.8 ± 21.9 |
All values are expressed as means ± SD (n = 3)
EC ethyl cellulose, ERL Eudragit RL 100, AZT zidovudine, DBS dibuthyl sebacate