Table I.

Effect of CDs on the Dissolution Efficiency of Efavirenz

Product	Dissolution efficiency 0–30 min	Dissolution efficiency 0–180 min
Efavirenz	1.51 ± 0.645	5.64 ± 1.149
Effect of βCD efavirenz
Physical mixture	6.78 ± 0.170*	18.74 ± 2.100**
Kneaded mixture	9.34 ± 1.364**	30.95 ± 0.058***
Freeze-dried mixture	11.26 ± 1.304***	31.16 ± 2.189***
Effect of HPβCD efavirenz
Physical mixture	9.74 ± 1.177**	21.08 ± 1.900***
Kneaded mixture	33.04 ± 0.625***	49.98 ± 1.053***
Freeze-dried mixture	29.87 ± 1.805***	54.25 ± 1.031***
Effect of RMβCD efavirenz
Physical mixture	7.47 ± 0.573**	19.84 ± 1.425**
Kneaded mixture	8.60 ± 1.552**	24.58 ± 2.684***
Freeze-dried mixture	12.78 ± 0.317***	43.13 ± 0.331***

*P < 0.05; **P < 0.01; ***P < 0.001 versus efavirenz