Fig. 5.

Blood glucose levels in a normal rats and b streptozocin-diabetic rats (n = 6). Control group were treated orally with CMC 1% suspension, control beads groups were administrated orally suspension of placebo chitosan beads in CMC 1%, gliclazide powder, and gliclazide beads groups were administered as much as 10 mg/kg of pure drug and the loaded chitosan beads containing the same amount of pure gliclazide suspended in 1% (w/v) carboxymethylcellulose (CMC) suspension in normal saline, respectively, and NPH insulin group received 2.5 IU/kg of NPH insulin subcutaneously. *p < 0.05