Table 2.
MCF-7 Tumor-to-Blood (T:B) Ratios and T:B Area Under Curve (AUC) Ratios for 111In-CHX-A″-DTPA hu3S193 Multimer, diabody, and F(ab′)2
| Time point | Hu3S193 Multimer | Hu3S193 Diabodya | Hu3S193 F(ab′)2 |
|---|---|---|---|
| 10 minutes | 1:14.7 | 1:12 | 1:17.8 |
| 30 minutes | 1:4.5 | 1:2 | — |
| 1 hour | 1:3.2 | 1:2 | 1:4.2 |
| 2 hours | 1:1.3 | 2:1 | 1:1.8 |
| 4 hours | 1.3:1 | 5:1 | — |
| 6 hours | 3.9:1 | — | 1.4:1 |
| 8 hours | 6.4:1 | 20:1 | 2:1 |
| 24 hours | 26.3:1 | 30:1 | 8.3:1 |
| 48 hours | 46:1 | 40:1 | — |
| 72 hours | 57:1 | — | 15.6:1 |
| 120 hours | 46:1 | — | — |
| Hu3S193 Multimer | Hu3S193 Diabody | Hu3S193 F(ab′)2 | |
|---|---|---|---|
| T:B AUC Ratio | 6.28: 1 | 6.32: 1 | 3.31: 1 |
a
From Tahtis et al.23