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. Author manuscript; available in PMC: 2009 Oct 7.
Published in final edited form as: Phys Med Biol. 2008 Aug 29;53(19):R319–R350. doi: 10.1088/0031-9155/53/19/R01

Figure 4.

Figure 4

Longitudinal in vivo imaging of the progression of osteoarthritis (OA) in a rat model. The acquisition protocol (80 kVp, 190 mAs, 210 views) was designed to provide an appropriate entrance exposure (36 cGy) for repeated imaging. The same limb has been imaged before surgery (a,c) and two months following surgery (anterior cruciate ligament transection and partial meniscectomy) to induce OA (b,d). Post-surgery images demonstrate significant reduction in joint space (JS) in the medial compartment, remodeling of subchondral bone (SB), and pathological calcification of the patellar tendon (PT). 3D surface models of the joint (a,b) demonstrate the striking derangement of the joint over a period of 2 months; note the change in alignment of the femur (F) and tibia (T). Images courtesy of David McErlain, Robarts Research Institute, University of Western Ontario.