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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Aug 25;327(2):482–490. doi: 10.1124/jpet.108.142224

Figure 1. Effects of URB597 on development of nicotine-induced CPP.

Figure 1

(a) Nicotine doses ranging from 0.1 mg/kg to 1.0 mg/kg produced significant CPP (*P<0.05 vs corresponding pre-test; n=8–10). (b) When rats were pre-treated with URB597 (0.3 mg/kg) before each nicotine conditioning session, CPP did not develop (P=ns; n=8–10) and URB597 did not potentiate effects of a low 0.05 mg/kg ineffective threshold dose of nicotine. All data are expressed as time spent in sec (mean ± SEM) in the nicotine-paired compartment during 15-min Pre-test (open bars), Test (filled black bars),