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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Aug 25;327(2):482–490. doi: 10.1124/jpet.108.142224

Figure 6. Effects of URB597 and nicotine on food-reinforced responding and locomotor activity.

Figure 6

(a) URB597 (0.3 mg/kg i.p.) given acutely before the session did not disrupt food-maintained responding either alone or in combination with different doses of nicotine (0.01 to 0.4 mg/kg s.c.). Rates of responding (responses/second) on the active lever associated with food reinforcement are shown as a function of nicotine dose (mg/kg, log scale). Data are expressed as responses per sec (mean ± SEM; n=16). (b) URB597 (0.3 mg/kg i.p.) also failed to modify the effects of any dose of nicotine (0.05 to 1.0 mg/kg s.c.) on locomotor activity. Data are expressed as distance traveled in cm (mean ± SEM; n=7) during a single daily session.