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. 2009 Apr 9;4(4):e5156. doi: 10.1371/journal.pone.0005156

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Subramanian et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Preferences for amino acids (single letter code) at P₁-P₄ and P₁′-P₄′ are shown schematically. At each position, the height of each amino acid corresponds to its frequency at cleavage sites based on analysis of α and β globin. WebLogo (weblogo.berkeley.edu), a free software for plotting consensus sequences, was used to plot P_4- P₄′ preferences.