Figure 4.

Incidence of all renal events according to achieved BP levels, adjusted for age, gender, duration of diabetes, glycosylated hemoglobin, currently treated hypertension, history of macrovascular disease, electrocardiogram abnormalities (ventricular hypertrophy, Q waves, or atrial fibrillation), triglycerides, LDL cholesterol, HDL cholesterol, body mass index, current smoking, current alcohol use, and study drug. Solid boxes represent estimates of event rates, centers of which are placed at the intersection of the point estimate and median SBP value. Areas of the boxes are proportional to the number of events, and vertical bars represent 95% CI. The rate of all renal events was significantly associated with achieved SBP levels (P < 0.0001 for trend).