Fig. 3.

Correction of embryonic p57^KO mouse phenotypes in p57^p27KI mice. (A) Representative examples of the whole body, lens, and palate at E18.5, as well as of the intestine at P0. The growth retardation, cataracts in the lens (stained with hematoxylin–eosin), cleft palate (arrowhead), and short intestine of p57^KO mice were corrected in p57^p27KI mice. (Scale bars: macroscopic comparisons, 5 mm; lens sections, 100 μm.) (B) Representative examples of the adrenal gland at P0. Vertical lines indicate comparison of the major axis between the glands from p57^KO and p57^p27KI mice. (C) Representative examples of skeletal staining of E18.5 embryos. Red and black arrowheads indicate the ossification of occipital bone and digits, respectively. (Scale bars: whole body, 5 mm; digits, humerus, and femur, 1 mm.)