Table 4.
Dietary calcium regulates suppression of EAE by 1,25(OH)2D3 and calcitonin
| Dietary Ca | Treatment | Incidence | Day of onset | Peak severity | CDI |
|---|---|---|---|---|---|
| 0.25% | 0 ng 1,25D3 + Veh | 100% (10/10) | 14 ± 3 | 3.5 ± 0.7 | 29 ± 10 |
| 1.0% | 0 ng 1,25D3 + Veh | 90% (9/10) | 13 ± 2 | 3.4 ± 0.9 | 28 ± 16 |
| 0.25% | 1 ng 1,25D3 + CT | 78% (7/9) | 14 ± 2 | 3.7 ± 0.8 | 23 ± 16 |
| 1.0% | 1 ng 1,25D3 + CT | 67% (6/9) | 17 ± 4 | 2.4 ± 0.7† | 10 ± 10** |
| 0.25% | 5 ng 1,25D3 + CT | 60% (3/5) | 19 ± 1* | 3.3 ± 0.6 | 8 ± 9** |
| 1.0% | 5 ng 1,25D3 + CT | 0% (0/5)* | NA | NA | 0** |
Experiments were performed as described in Fig. 4. The clinical data demonstrate the mean ± SD from 1 representative of 2 individual experiments. *, P < 0.05 compared to both vehicle groups.
**, P < 0.05 compared to both vehicle groups and the 0.25% Ca 1-ng 1,25(OH)2D3 + CT group. NA, not applicable.