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IMS2186 reduces PGE2 production in vitro. The effect of IMS2186 on LPS-induced PGE2 production by THP-1 cells was evaluated in vitro by ELISA. Differentiated THP-1 cells were treated with indicated concentrations of IMS2186 in the presence of 1 μg/ml LPS. Cells treated with LPS alone were used as an induction control (LPS). PGE2 level in cells without LPS treatment was designated as the basal control (CNTL). IMS2186 inhibited PGE2 production in a dose-dependent manner.
