Table 2.
Association between 8q24 SNPs and 9 smoking-related cancer sites
| 8q24 SNPs |
rs1447295 C>A | rs16901979 C>A | rs6983267 G>T | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cancer Site genotype |
Case/ control |
ORcrude (95% CI) | ORadj (95% CI)* | genotype | Case/ control |
ORcrude (95% CI) | ORadj (95% CI)* | genotype | Case/ control |
ORcrude (95% CI) | ORadj (95% CI)* | |
| LA study | ||||||||||||
| Lung | ||||||||||||
| CC | 403/714 | 1.00 | 1.00 | CC | 429/786 | 1.00 | 1.00 | TT | 123/194 | 1.00 | 1.00 | |
| CA | 124/197 | 1.12 (0.86, 1.44) | 0.94 (0.69, 1.28) | CA | 85/127 | 1.23 (0.91, 1.65) | 0.79 (0.52, 1.18) | TG | 225/441 | 0.81 (0.61, 1.06) | 0.78 (0.56, 1.10) | |
| AA | 13/20 | 1.15 (0.57, 2.34) | 0.73 (0.31, 1.72) | AA | 19/16 | 2.18 (1.11, 4.27) | 1.25 (0.55, 2.85) | GG | 192/291 | 1.04 (0.78, 1.39) | 1.02 (0.70, 1.58) | |
| Ptrend | 0.38 | 0.49 | 0.016 | 0.68 | 0.56 | 0.80 | ||||||
| CA&AA | 137/217 | 1.12 (0.87, 1.43) | 0.92 (0.68, 1.24) | CA&AA | 104/143 | 1.33 (1.01, 1.76) | 0.84 (0.57, 1.23) | GG** | 192/291 | 1.20 (0.96, 1.51) | 1.21 (0.90, 1.61) | |
| UADT (squamous) | ||||||||||||
| CC | 301/714 | 1.00 | 1.00 | CC | 314/785 | 1.00 | 1.00 | TT | 78/194 | 1.00 | 1.00 | |
| CA | 92/196 | 1.11 (0.84, 1.48) | 1.00 (0.73, 1.36) | CA | 73/127 | 1.44 (1.05, 1.97) | 1.31 (0.89, 1.93) | TG | 154/441 | 0.87 (0.63, 1.20) | 0.87 (0.61, 1.23) | |
| AA | 8/20 | 0.95 (0.41, 2.18) | 0.67 (0.26, 1.70) | AA | 14/16 | 2.19 (1.06, 4.54) | 1.65 (0.71, 3.82) | GG | 168/290 | 1.44 (1.04, 1.99) | 1.53 (1.06, 2.21) | |
| Ptrend | 0.59 | 0.66 | 0.0030 | 0.11 | 0.0056 | 0.0071 | ||||||
| CA&AA | 100/216 | 0.93 (0.41, 2.12) | 0.67 (0.27, 1.69) | CA&AA | 87/143 | 1.52 (1.13, 2.05) | 1.34 (0.92, 1.95) | GG** | 168/290 | 1.59 (1.24, 2.02) | 1.69 (1.28, 2.24) | |
| UADT stratified | ||||||||||||
| Oropharynx | ||||||||||||
| CC | 183/714 | 1.00 | 1.00 | CC | 193/785 | 1.00 | 1.00 | TT | 51/194 | 1.00 | 1.00 | |
| CA | 51/196 | 1.02 (0.72, 1.44) | 0.96 (0.66, 1.40) | CA | 41/127 | 1.31 (0.89, 1.93) | 1.45 (0.91, 2.31) | TG | 86/441 | 0.74 (0.51, 1.09) | 0.75 (0.50, 1.13) | |
| AA | 4/20 | 0.78 (0.26, 2.31) | 0.68 (0.22, 2.13) | AA | 5/16 | 1.27 (0.46, 3.51) | 1.18 (0.39, 3.58) | GG | 100/290 | 1.31 (0.89, 1.92) | 1.48 (0.97, 2.26) | |
| Ptrend | 0.87 | 0.61 | 0.18 | 0.19 | 0.052 | 0.024 | ||||||
| CA&AA | 55/216 | 0.99 (0.71, 1.39) | 0.94 (0.65, 1.35) | CA&AA | 46/143 | 1.31 (0.91, 1.89) | 1.42 (0.91, 2.23) | GG** | 100/290 | 1.60 (1.19, 2.14) | 1.80 (1.30, 2.49) | |
| Larynx | ||||||||||||
| CC | 55/714 | 1.00 | 1.00 | CC | 59/785 | 1.00 | 1.00 | TT | 14/194 | 1.00 | 1.00 | |
| CA | 21/196 | 1.39 (0.82, 2.36) | 1.65 (0.92, 2.97) | CA | 13/127 | 1.36 (0.73, 2.56) | 0.78 (0.32, 1.92) | TG | 25/441 | 0.79 (0.40, 1.54) | 0.68 (0.32, 1.47) | |
| AA | 2/20 | 1.30 (0.30, 5.70) | 0.69 (0.08, 5.60) | AA | 5/16 | 4.16 (1.47, 11.75) |
2.79 (0.68, 11.54) |
GG | 37/290 | 1.77 (0.93, 3.36) | 1.56 (0.71, 3.46) | |
| Ptrend | 0.24 | 0.90 | 0.016 | 0.55 | 0.022 | 0.14 | ||||||
| CA&AA | 23/216 | 1.38 (0.83, 2.30) | 1.55 (0.88, 2.75) | CA&AA | 18/143 | 1.68 (0.96, 2.92) | 0.95 (0.41, 2.19) | GG** | 37/290 | 2.08 (1.30, 3.33) | 2.04 (1.12, 3.72) | |
| Nasopharynx | ||||||||||||
| CC | 29/714 | 1.00 | 1.00 | CC | 24/785 | 1.00 | 1.00 | TT | 6/194 | 1.00 | 1.00 | |
| CA | 8/196 | 1.01 (0.45, 2.23) | 0.76 (0.32, 1.81) | CA | 12/127 | 3.09 (1.51, 6.34) | 1.88 (0.80, 4.43) | TG | 23/441 | 1.69 (0.68, 4.21) | 1.75 (0.66, 4.65) | |
| AA | 2/20 | 2.46 (0.55, 11.0) | 1.64 (0.32, 8.51) | AA | 3/16 | 6.13 (1.68, 22.5) | 2.48 (0.53, 11.5) | GG | 11/290 | 1.23 (0.45, 3.37) | 1.65 (0.54, 5.03) | |
| Ptrend | 0.50 | 0.93 | 0.00012 | 0.11 | 0.85 | 0.42 | ||||||
| CA&AA | 10/216 | 1.14 (0.55, 2.38) | 0.85 (0.38, 1.91) | CA&AA | 15/143 | 3.43 (1.76, 6.70) | 1.96 (0.87, 4.45) | TG&GG | 34/731 | 1.50 (0.62, 3.63) | 1.72 (0.67, 4.45) | |
| Esophagus (squamous) |
||||||||||||
| CC | 22/714 | 1.00 | 1.00 | CC | 23/785 | 1.00 | 1.00 | TT | 5/194 | 1.00 | 1.00 | |
| CA | 8/196 | 1.33 (0.58, 3.02) | 1.43 (0.58, 3.47) | CA | 6/127 | 1.61 (0.64, 4.04) | 1.28 (0.42, 3.86) | TG | 13/441 | 1.14 (0.40, 3.25) | 1.21 (0.40, 3.68) | |
| AA | 0/20 | -- | -- | AA | 1/16 | 2.13 (0.27, 16.8) | 1.48 (0.16, 14.1) | GG | 13/290 | 1.74 (0.61, 3.25) | 2.49 (0.75, 8.24) | |
| Ptrend | 0.89 | 0.90 | 0.23 | 0.62 | 0.24 | 0.10 | ||||||
| CA&AA | 8/216 | 1.20 (0.53, 2.74) | 1.26 (0.52, 3.09) | CA&AA | 7/143 | 1.57 (0.70, 3.97) | 1.30 (0.45, 3.78) | GG** | 13/290 | 1.58 (0.77, 3.27) | 2.16 (0.93, 5.06) | |
| Other (squamous)† | ||||||||||||
| CC | 12/714 | 1.00 | 1.00 | CC | 15/785 | 1.00 | 1.00 | TT | 2/194 | 1.00 | 1.00 | |
| CA | 4/196 | 1.21 (0.38, 3.81) | 1.45 (0.44, 4.78) | CA | 1/127 | 0.42 (0.05, 3.15) | 0.43 (0.04, 4.40) | TG | 7/441 | 1.54 (0.32, 7.48) | 1.26 (0.25, 6.38) | |
| AA | 0/20 | -- | -- | AA | 0/16 | -- | -- | GG | 7/290 | 2.34 (0.48, 11.4) | 2.26 (0.44, 11.5) | |
| Ptrend | 0.98 | 0.75 | 0.32 | 0.42 | 0.25 | 0.25 | ||||||
| CA&AA | 4/216 | 1.10 (0.35, 3.45) | 1.35 (0.41, 4.47) | CA&AA | 1/143 | 0.37 (0.05, 2.79) | 0.40 (0.04, 4.13) | TG&GG | 14/731 | 1.86 (0.42, 8.24) | 1.62 (0.35, 7.40) | |
| Esophagus (adenocarcinoma) |
||||||||||||
| CC | 50/714 | 1.00 | 1.00 | CC | 60/785 | 1.00 | 1.00 | TT | 14/194 | 1.00 | 1.00 | |
| CA | 16/196 | 1.17 (0.65, 2.09) | 1.23 (0.66, 2.29) | CA | 7/127 | 0.72 (0.32, 1.61) | 1.03 (0.43, 2.50) | TG | 37/441 | 1.16 (0.61, 2.2) | 1.22 (0.63, 2.37) | |
| AA | 1/20 | 0.72 (0.09, 5.43) | 0.65 (0.08, 5.50) | AA | 0/16 | -- | -- | GG | 15/290 | 0.72 (0.34, 1.52) | 0.95 (0.43, 2.10) | |
| Ptrend | 0.81 | 0.76 | 0.21 | 0.74 | 0.33 | 0.89 | ||||||
| CA&AA | 17/216 | 1.12 (0.64, 1.99) | 1.17 (0.64, 2.15) | CA&AA | 7/143 | 0.64 (0.28, 1.43) | 0.95 (0.39, 2.29) | GG** | 15/290 | 0.64 (0.36, 1.16) | 0.83 (0.44, 1.55) | |
| Taixing Study | ||||||||||||
| Esophagus | ||||||||||||
| CC | 137/276 | 1.00 | 1.00 | CC | 112/207 | 1.00 | 1.00 | TT | 66/146 | 1.00 | 1.00 | |
| CA | 59/101 | 1.18 (0.80, 1.72) | 1.18 (0.79, 1.74) | CA | 74/143 | 0.96 (0.67, 1.38) | 0.96 (0.66, 1.40) | TG | 95/165 | 1.27 (0.87, 1.87) | 1.18 (0.79, 1.75) | |
| AA | 2/11 | 0.37 (0.08, 1.68) | 0.41 (0.09, 1.91) | AA | 14/30 | 0.86 (0.44, 1.69) | 1.00 (0.50, 1.99) | GG | 40/74 | 1.20 (0.74, 1.94) | 1.06 (0.64, 1.76) | |
| Ptrend | 0.98 | 0.92 | 0.66 | 0.89 | 0.36 | 0.70 | ||||||
| CA&AA | 61/112 | 1.10 (0.76, 1.59) | 1.10 (0.75, 1.63) | CA&AA | 88/173 | 0.94 (0.67, 1.33) | 0.97 (0.68, 1.38) | GG** | 40/74 | 1.04 (0.68, 1.60) | 0.97 (0.62, 1.52) | |
| Stomach | ||||||||||||
| CC | 140/276 | 1.00 | 1.00 | CC | 107/207 | 1.00 | 1.00 | TT | 61/146 | 1.00 | 1.00 | |
| CA | 39/101 | 0.76 (0.50, 1.16) | 0.80 (0.51, 1.24) | CA | 69/143 | 0.93 (0.65, 1.35) | 0.96 (0.65, 1.42) | TG | 94/165 | 1.36 (0.92, 2.02) | 1.21 (0.79, 1.83) | |
| AA | 8/11 | 1.43 (0.56, 3.65) | 1.57 (0.56, 4.40) | AA | 16/30 | 1.03 (0.54, 1.98) | 1.26 (0.62, 2.55) | GG | 32/74 | 1.04 (0.62, 1.73) | 0.88 (0.51, 1.51) | |
| Ptrend | 0.63 | 0.79 | 0.89 | 0.76 | 0.62 | 0.82 | ||||||
| CA&AA | 47/112 | 0.83 (0.56, 1.23) | 0.86 (0.57, 1.32) | CA&AA | 85/173 | 0.95 (0.67, 1.35) | 1.00 (0.69, 1.45) | TG&GG | 126/239 | 1.26 (0.87, 1.82) | 1.10 (0.74, 1.63) | |
| Liver | ||||||||||||
| CC | 128/276 | 1.00 | 1.00 | CC | 99/207 | 1.00 | 1.00 | TT | 54/146 | 1.00 | 1.00 | |
| CA | 52/101 | 1.11 (0.75, 1.65) | 1.30 (0.84, 2.02) | CA | 74/143 | 1.08 (0.75, 1.56) | 1.20 (0.80, 1.81) | TG | 88/165 | 1.44 (0.96, 2.16) | 1.51 (0.96, 2.38) | |
| AA | 7/11 | 1.37 (0.52, 3.62) | 1.36 (0.47 3.93) | AA | 14/30 | 0.98 (0.50, 1.92) | 1.13 (0.53, 2.43) | GG | 45/74 | 1.64 (1.01, 2.67) | 1.54 (0.89, 2.65) | |
| Ptrend | 0.45 | 0.22 | 0.84 | 0.46 | 0.034 | 0.091 | ||||||
| CA&AA | 59/112 | 1.14 (0.78, 1.66) | 1.31 (0.86, 1.99) | CA&AA | 88/173 | 1.06 (0.75, 1.51) | 1.19 (0.80, 1.76) | TG&GG | 134/239 | 1.51 (1.03, 2.19) | 1.51 (0.99, 2.31) | |
| MSKCC | ||||||||||||
| Bladder | ||||||||||||
| CC | 152/140 | 1.00 | 1.00 | CC | 154/149 | 1.00 | 1.00 | TT | 37/34 | 1.00 | 1.00 | |
| CA | 18/17 | 0.98 (0.48, 1.97) | 0.59 (0.21, 1.64) | CA | 17/9 | 1.83 (0.79, 4.23) | 2.31 (0.74, 7.23) | TG | 90/73 | 1.13 (0.65, 1.98) | 0.92 (0.41, 2.09) | |
| AA | 2/0 | -- | AA | 0/0 | -- | -- | GG | 44/50 | 0.81 (0.44, 1.50) | 0.49 (0.19, 1.25) | ||
| Ptrend | 0.60 | 0.47 | 0.16 | 0.15 | 0.43 | 0.11 | ||||||
| CA&AA | 20/17 | 1.08 (0.55, 2.15) | 0.63 (0.23, 1.72) | CA&AA | -- | -- | GG** | 44/50 | 0.74 (0.46, 1.20) | 0.52 (0.25, 1.07) | ||
*
lung cancer adjusted for gender, smoking, education, race, and age; UADTs adjusted for gender, smoking, education, race, age, and alcohol drinking; Taixing City esophagus adjusted for: gender, smoking, age, alcohol drinking; stomach cancer adjusted for age, gender, smoking, alcohol drinking and H.Pylori; infection; liver cancer adjusted for age, gender, smoking, alcohol drinking, and HBsAg status; bladder cancer adjusted for gender, smoking, race, and age.
**
For rs6983267 TT & TG served as the referent in the recessive model for the following sites: lung, UADT (combined), oropharynx, larynx, esophagus (squamous and adenocarcinoma), bladder, and kidney.
†
Other (squamous) are sites 30.0, 31.1, and 31.1 as defined by ICD-O-2.