Table 4.

False positive report probability (FPRP) values for associations between 8q24 variants and smoking-related cancer sites

					Prior probability
SNP	Stratum	ORadj (95% CI)*	Power†	Reported p-values*	0.5	0.25	0.1	0.01	0.001
rs6983267	UADT	1.69 (1.28, 2.24)	0.90	0.00021	0.0013	0.0038	0.011	0.11	0.56
rs6983267	Oropharynx	1.80 (1.30, 2.49)	0.76	0.00042	0.0028	0.0085	0.025	0.22	0.74
rs6983267	Larynx	2.04 (1.12, 3.72)	0.43	0.020	0.11	0.28	0.53	0.93	0.99
rs6983267	Liver	1.51 (0.99, 2.31)	0.54	0.034	0.11	0.26	0.52	0.92	0.99
rs16901979	UADT never-smokers	1.86 (1.06, 3.28)	0.33	0.032	0.12	0.30	0.56	0.93	0.99
rs16901979	Oropharynx never-smokers	2.28 (1.19, 4.39)	0.27	0.014	0.12	0.28	0.54	0.93	0.99
rs6983267	Lung ever-smokers	1.45 (1.05, 2.00)	0.83	0.024	0.039	0.11	0.27	0.80	0.99
rs6983267	UADT never-smokers	1.56 (1.01, 2.39)	0.50	0.045	0.087	0.22	0.46	0.91	0.99
rs6983267	UADT ever-smokers	1.79 (1.23, 2.61)	0.74	0.002	0.014	0.040	0.11	0.58	0.93
rs6983267	Oropharynx ever-smokers	2.01 (1.29, 3.11)	0.55	0.002	0.018	0.052	0.14	0.64	0.95
rs6983267	Larynx ever-smokers	2.05 (1.09, 3.85)	0.27	0.25	0.13	0.32	0.58	0.94	0.99
rs1447295	Liver ever-smokers	1.96 (1.07, 3.59)	0.30**	0.032	0.13	0.32	0.58	0.94	0.99
rs6983267	Bladder ever-smokers	0.35 (0.14, 0.83)	0.12	0.017	0.19	0.42	0.68	0.96	1.0

^*Odds ratios from tables 2 and 3.

^†Statistical power calculated using the recessive model, except where noted, is the power to detect an odds ratio of 1.5 or 0.67, at α level of 0.05.

^**Statistical power calculated using the dominant model.