Table 3.

Hazard ratios for total and cause-specific mortality by age group and vitamin and mineral treatment factor for the total 15¼ year follow-up for endpoints and factors with statistically significant or close to statistically significant interactions^*

	Age group‡		P for age group interaction
Cause of death and treatment factor†	<55 years at random assignment, HR (95% CI)	≥55 years at random assignment, HR (95% CI)
Total mortality (n = 9727)
Factor C (vs no factor C)	0.89 (0.83 to 0.96)	1.01 (0.97 to 1.06)	.002
Factor D (vs no factor D)	0.88 (0.82 to 0.95)	0.98 (0.93 to 1.03)	.023
Total cancer mortality (n = 3242)
Factor C (vs no factor C)	0.93 (0.83 to 1.03)	1.12 (1.02 to 1.22)	.016
Factor D (vs no factor D)	0.85 (0.76 to 0.95)	1.02 (0.94 to 1.12)	.019
Esophageal cancer mortality (n = 1515)
Factor C (vs no factor C)	0.96 (0.81 to 1.12)	1.18 (1.04 to 1.35)	.058
Factor D (vs no factor D)	0.83 (0.71 to 0.98)	1.14 (1.00 to 1.30)	.003

^*HR = hazard ratio; CI = confidence interval.

^†Factor C = ascorbic acid (120 mg/d) + molybdenum (30 μg/d); factor D = selenium (50 μg/d) + vitamin E (30 mg/d) + beta-carotene (15 mg/d).

^‡HRs (95% CIs) adjusted for the other three treatments factors, age (continuous), sex, and commune (four communes).