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Chiral imidazolium catalyzed annulations.a
 | ||||
|---|---|---|---|---|
| entry | R | % yieldb | 7:5c | % eed |
| 1 (a) | Ph | 85 | 5:1 | 99; 6 |
| 2 (b) | p-BrC6H4 | 76 | 3e:1 | 99; 4 |
| 3 (c) | 2-furyl | 80 | 3:1 | 99; 8 |
| 4 (d) | 2-thiophenyl | 68 | 3:1 | 99; 28 |
See Supporting Information for reaction details.
Total isolated yields of lactone products.
Determined by 1H NMR analysis of unpurified reaction mixtures.
Determined by SFC analysis on chiral columns.
Structure determined by X-ray analysis of the product from ent-2•ClO4.
