Table 4.

Inhibition of NOS isozymes by synthetic inhibitors

	Ki (μM)*			Selectivity
Compounds	nNOS	eNOS	iNOS	n/e	n/i
(±)-7	1.18	1450	161	1230	136
(±)-8	2.42	1450	238	600	98
(±)-9	2.3	1450	297	632	129
(±)-10	3.33	140	195	42	59
(±)-11	1.36	424	200	312	147
(±)-12	1.26	243	174	193	138
(±)-13	2.74	181	425	66	155
(±)-14	3.34	108	222	32	66
(±)-15	0.098	283	5.84	2890	60
(±)-16	0.085	85	8.95	1000	106
(±)-17	0.104	83	9.48	800	91
(±)-18	0.197	84	14.1	428	72
(±)-19	0.144	130	7.97	905	55
(±)-20	0.206	116	13.6	564	66
(±)-21	0.159	72	9.01	451	57
(±)-22	0.157	41	3.56	260	23
(±)-23	0.110	30	7.7	272	70
(±)-24	0.024	78	5.4	3230	222
(±)-25	0.027	18	4.6	656	170
(±)-26	0.014	28	4.06	2000	290
(±)-27	18.8	141	232	7.5	12
(±)-28	0.551	164	10.6	297	19
(±)-29	0.136	40.0	12.2	294	90
(±)-30	0.393	125	22.8	319	58
(±)-31	0.326	92.4	38.2	284	117
(±)-32	1.21	48.9	56.6	40	47

^*The apperent K_i values are represented as the mean from two or more independent experiments preformed in duplicate with five or six data points each and correlation coefficients of 0.89-0.99. The experimental standard deviations were less than 10%.