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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Neuropsychopharmacology. 2007 Jun 20;33(5):1137–1148. doi: 10.1038/sj.npp.1301477

Figure 5.

Figure 5

Effects of 3 consecutive challenge administrations of saline (upper panel) and methylphenidate (2.5 mg/kg; lower panel) on locomotor activity in separate groups of rats treated previously with nicotine (0.2-0.8 mg/kg) or saline (n=8 per group). Data are expressed as the mean (±SEM) distance traveled (cm) during each challenge day as a function of prior nicotine treatment dose. Asterisk indicates a significant difference from the saline control value on the corresponding treatment day (*p<.05).