Table 3.
Effect estimates and P-values for tests of association between nine purported obesity-risk variants and adipose traits measured using DEXA (n = 2206)
| Nearest gene | SNP | Total adipose mass (kg) |
Abdominal adipose mass (kg) |
Gynoid adipose mass (kg) |
|||
|---|---|---|---|---|---|---|---|
| β | P-value | β | P-value | β | P-value | ||
| FTO | rs1121980 | 0.91 | 0.0007 | 0.05 | 0.0008 | 0.07 | 0.004 |
| SH2B1 | rs7498665 | 0.32 | 0.24 | 0.02 | 0.17 | 0.03 | 0.28 |
| MTCH2 | rs4752856 | 0.38 | 0.16 | 0.03 | 0.04 | 0.04 | 0.12 |
| MC4R | rs17782313 | 0.46 | 0.15 | 0.02 | 0.20 | 0.02 | 0.36 |
| NEGR1 | rs2815752 | 0.23 | 0.41 | 0.02 | 0.14 | 0.03 | 0.18 |
| GNPDA2 | rs10938397 | 0.44 | 0.12 | 0.03 | 0.06 | 0.05 | 0.05 |
| TMEM18 | rs6548238 | 0.30 | 0.38 | 0.00 | 0.91 | 0.03 | 0.32 |
| KCTD15 | rs11084753 | 0.07 | 0.80 | 0.00 | 0.92 | 0.02 | 0.51 |
| PCSK1 | rs6235 | 0.15 | 0.62 | 0.00 | 0.95 | 0.01 | 0.62 |
| GBS (SD units) | – | 0.76 | 0.0001 | 0.04 | 0.0004 | 0.06 | 0.0002 |
β Indicates the difference in adipose mass per copy of the risk allele at each locus. Data are from separate generalized linear models, assuming an additive mode of genetic inheritance and adjusted for age and sex. GBS = genetic burden score.