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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Circ Res. 2008 May 29;102(12):e120–e131. doi: 10.1161/CIRCRESAHA.107.167486

Figure 2.

Figure 2

Activation of PMNs with fMLP increases caveolae-mediated endocytosis of albumin in endothelial cells. A, Activation of PMNs with fMLP increased 125I-albumin endocytosis in a PMN number-dependent manner. B, Time course of effects of fMLP activation of PMNs (107 cells/mL) on 125I-albumin endocytosis. C, Effect of pretreatment of RLMVECs with MβCD on PMN-induced (107 cells/mL) 125I-albumin endocytosis. Results are representative of 3 experiments. Scale bars=10 μm. n=4 to 6 for each group (A and C) and time point (B). *P<0.05 compared with control group (without PMNs and fMLP), †P<0.05 compared with respective groups. D, Confocal images showing effect of fMLP activation of PMNs induced a PMN number-dependent increase in uptake of Alexa 488–labeled albumin (green). The nucleus (blue) was stained with DAPI. Results are representative of 3 experiments.