Table 5.

MIC of the 5″-Modified Neomycin Derivatives against Other Strains of Bacteria ^a

entry	Compound	K. pneumoniae b	K. pneumoniae c	S. aureus d	P. aeruginosa e	E. faecalisf	E. faecalisg
1	5b	8-16	16-32	2-4	4	2-4	4-8
2	5c	8-16	32	4-8	8-16	4-8	8-16
3	5f	4	8	16-32	8-16	32-64	≥ 250
4	5q	4	8	32	16-32	64-125	≥ 250
5	Neomycin B	4	16-32	125	64	64-125	≥ 250
6	Amikacin	1	0.5	8-16	0.5-1	32-64	≥ 250
7	Gentamicin	1	8	2-4	0.5-1	8-16	≥ 250
8	Vancomycin	ND	ND	ND	ND	ND	125

^aUnit: μg/mL, ND: Not Determined,

^bKlebsiella pneumoniae (ATCC 13883),

^cK. pneumoniae (ATCC 700603),

^dStaphylococcus aureus (ATCC 33591) (MRSA),

^ePseudomonas aeruginosa (ATCC 27853),

^fEnterococcus faecalis (ATCC 29212),

^gE. faecalis (ATCC51299) (VRE).