Table 2.

Long-term relative risks^* (95% confidence interval) of mortality/myocardial infarction among 81,875 women without prior coronary heart disease, stroke, or cancer at baseline followed from 1992 to 2004^†, according to categories of depression symptom score

	Depression symptom score
Outcome	86–100 (Referent)	76–85	53–75	0–52 (Depressive)	P for trend‡ (continuous)
Person-years	311391	293969	201794	54932
Sudden Cardiac Death
No. of cases	46	37	43	12
Age-adjusted	1.0	0.98 (0.64–1.51)	1.72 (1.13–2.61)	1.96 (1.03–3.71)	<0.001
Multivariable I	1.0	0.91 (0.59–1.41)	1.36 (0.89–2.08)	1.36 (0.71–2.61)	0.050
Multivariable II	1.0	0.87 (0.56–1.34)	1.27 (0.83–1.94)	1.21 (0.63–2.33)	0.13
Fatal CHD
No. of cases	171	147	159	64
Age-adjusted	1.0	1.01 (0.81–1.25)	1.67 (1.35–2.08)	2.81 (2.11–3.75)	<0.001
Multivariable I	1.0	0.93 (0.74–1.15)	1.30 (1.04–1.62)	1.79 (1.33–2.40)	<0.001
Multivariable II	1.0	0.86 (0.69–1.07)	1.14 (0.91–1.42)	1.49 (1.11–2.00)	0.007
Myocardial infarction
No. of cases	406	392	298	87
Age-adjusted	1.0	1.10 (0.95–1.26)	1.27 (1.09–1.47)	1.49 (1.18–1.87)	<0.001
Multivariable I	1.0	1.05 (0.92–1.21)	1.14 (0.98–1.33)	1.24 (0.98–1.57)	0.02
Multivariable II	1.0	1.03 (0.89–1.18)	1.08 (0.93–1.25)	1.13 (0.90–1.43)	0.19

CHD=coronary heart disease

^*Hazard ratios from proportional hazards models with time-dependent variables.

^†Women who responded to the MHI-5 items on any of the 1992, 1996, or 2000 questionnaires and were free of prior coronary heart disease, stroke, or cancer at the time of their earliest questionnaire response were included in the analysis from this timepoint on. Please see methods for description of variables for Multivariable models I and II.

^‡P value reflects test for linear trend using MHI-5 score as continuous variable.