Table 1.
POB-DNA adducts in lung nuclear and mitochondrial DNA of rats treated with NNK and (S)-NNAL
| Week of treatment | fmol/mg DNA (mean ± S.D.)a | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7-POB-Gua | O2-POB-dThd | O6-POB-dGuo | ||||||||||
| NNK | (S)-NNAL | NNK | (S)-NNAL | NNK | (S)-NNAL | |||||||
| nDNA | mtDNA | nDNA | mtDNA | nDNA | mtDNA | nDNA | mtDNA | nDNA | mtDNA | nDNA | mtDNA | |
| 1 | 1310 (1) | 1770 (1) | 949±153 | 1730±196 | 1230 (1) | 2400 (1) | 1220±173 | 1900±143 | 44 (1) | 46 (1) | 38±7 | 32±10 |
| 2 | 1710 (2) | 2990 (2) | 1430±452 | 2390±40 | 1940 (2) | 4770 (2) | 2150±580 | 3170±141 | 41 (2) | 48 (2) | 35±8 | 38±13 |
| 5 | 2530±692 | 2900±692 | 1440±170 | 1980±48 | 3790±398 | 6260±947 | 3380±733 | 5680±268 | 48±6 | 62±3 | 25±2 | 62±5 |
| 10 | 2810±816 | 2920±175 | 1770±1270 | 2400±467 | 6990±2030 | 8080±205 | 6030±810 | 7170±2010 | 42±4 | 97±4 | 38±13 | 69±13 |
| 16 | NAb | NA | 1820±351 | 2250±112 | NA | NA | 4730±816 | 6790±563 | NA | NA | 40±12 | 99±10 |
| 20 | 1610±218 | 3350±136 | 1510 (2) | 2580 (2) | 5050±1600 | 11200±1820 | 3990 (2) | 9010 (2) | 31±7 | 141±43 | 19 (2) | 102 (2) |
a
N = 3, unless stated otherwise (N in parentheses); when N = 2, the cell contains mean of two analyses; when N = 1, the cell contains the result of a single analysis
b
NA, not analyzed (no samples available for this time-point).