Skip to main content
. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Neurotoxicol Teratol. 2008 Mar 21;30(5):448–454. doi: 10.1016/j.ntt.2008.03.063

Fig. 2.

Fig. 2

Respiratory effects of in utero methadone (striped bars) or morphine (gray bars) exposures compared to vehicle (black bars) during room air (RA) breathing (left column) and during 5% CO2 challenge (middle column). CO2 challenge induced delta response is shown as percent of baseline (RA breathing) (right column). Three major respiratory parameters, inspiratory volume (VI) (A–C), tidal volume (VT) (D–F) and breathing frequency (fR) (G–I) are shown. Several differences exist between methadone and morphine exposed pups. Vertical bars represent standard error (S.E). * p<0.05, ** p<0.01, *** p<0.001 vs. vehicle; ^^^ p<0.001 vs. morphine; a p<0.05 vs. 7-day same treatment; b p<0.05 vs. 14-day same treatment.