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. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: Neurotoxicol Teratol. 2008 Mar 21;30(5):448–454. doi: 10.1016/j.ntt.2008.03.063

Table 3.

Respiratory measurements of in utero opioid exposed neonatal guinea pigs

	Age		Room Air			5% CO₂
		Vehicle	Methadone	Morphine	Vehicle	Methadone	Morphine
T_I [sec]	3 days	0.18 ± 0.02	0.16 ± 0.01	0.14 ± 0.01^b	0.14 ± 0.01^a ^b	0.13 ± 0.00^b	0.13 ± 0.00^b
	7 days	0.19 ± 0.02	0.20 ± 0.02	0.18 ± 0.01	0.17 ± 0.01	0.13 ± 0.01^***	0.13 ± 0.00^***^b
	14 days	0.23 ± 0.01	0.20 ± 0.02	0.23 ± 0.02	0.16 ± 0.00	0.15 ± 0.01	0.16 ± 0.01

T_E [sec]	3 days	0.25 ± 0.03	0.25 ± 0.03	0.21 ± 0.01^b	0.17 ± 0.01^a ^b	0.17 ± 0.01^a ^b	0.17 ± 0.01^a ^b
	7 days	0.27 ± 0.03	0.27 ± 0.02	0.28 ± 0.02	0.23 ± 0.01	0.21 ± 0.01	0.21 ± 0.01
	14 days	0.32 ± 0.02	0.27 ± 0.02	0.33 ± 0.03	0.22 ± 0.01	0.22 ± 0.01	0.22 ± 0.01

V_T/T_I	3 days	3.8 ± 0.3	4.7 ± 1.1^{^^^}	10.4 ± 2.3^***^a ^b	13.2 ± 0.9	18.1 ± 1.2^**^a ^b	18.9 ± 1.2^***^a ^b
[ml^.sec⁻¹^.100g⁻¹]	7 days	3.7 ± 0.6	2.8 ± 0.2	3.7 ± 0.4	10.8 ± 0.5	11.2 ± 0.6^{^^}	15.3 ± 0.6^**^b
	14 days	2.7 ± 0.1	2.6 ± 0.1	2.8 ± 0.2	11.2 ± 1.1	11.4 ± 1.1	8.8 ± 0.7

^**

p<0.01 vs. vehicle

^***

p<0.001 vs. vehicle

^{^^}

p<0.01 vs. morphine

^{^^^}

p<0.001 vs. morphine

^a

p<0.05 vs. 7 day same treatment

^b

p<0.05 vs. 14 day same treatment, all values reported as mean ± S.E.