. Author manuscript; available in PMC: 2009 Aug 1.

Published in final edited form as: Bioorg Med Chem. 2008 Jun 20;16(15):7291–7301. doi: 10.1016/j.bmc.2008.06.030

Table 1.

Binding Affinity Constants of Compounds to Selected 5-HT and H-1 Receptors.

Compds	Binding Data of Compounds, Ki ± SEM (nM)						Ki D₂/Ki D₄ Ratio
Compds	DAD₂	DAD₄	5HT_1A	5HT_2A	5HT_2C	H-1	Ki D₂/Ki D₄ Ratio
Cloz (1)^a	130	54	140	8.9	17	1.8	2.4
Hal (2)^a	0.89	10	3600	120	4700	440	0.09
4^b	253.5±38.9	17.5±2.0	90.9±21.0	109.6±16.0	3552±943	157.6±36.0	2.8
5^b	1.6±0.14	5.3±1.0	27.7±8.0	30.9±6.0	872.1±178.0	8780±1625	0.30
6^b	2.3±0.28	19.2±2.3	37.6±6.0	12.3±3.0	>10,000	635.4±96.0	0.12
7^b	124.4±16.5	176.8±36.0	414.4±101.0	106.0±21.0	1065±244	973.5±207.0	0.70
(+)-8^b	51.1±6.0	3.6±0.48	772.3±90.0	75.8±12.0	3598±1162	1467±473	14.2
(-)-8^b	489.4±119.4	245.5±29.2	831.5±126.0	241.5±39.0	1252±461	259.6±34.0	2.0

Binding data obtained from reference 12b.

The synthesis and/or DA binding data of compounds previously reported in ref. 7 - ⁹