Table 2.
Frequencies of founder mutations in distinct categories of ovarian cancer patients
| Clinical variable | St.-Petersburg (n = 290) | Krasnodar (n = 64) |
| Age at onset (years) | ||
| < 41 | 2/36 (5.6%) | 1/1 (100.0%) |
| 41–60 | 22/172 (12.8%) | 9/33 (27.2%) |
| > 60 | 12/82 (14.6%) | 2/30 (6.7%) |
| Non-informative | - | |
| Family history* | ||
| Positive | 1/9 (11.1%) | - |
| Negative | 33/266 (12.4%) | - |
| Non-informative | 2/15 (13.3%) | 12/64 (18.8%) |
| T status | ||
| T1 | 2/52 (3.8%) | 3/10 (30.0%) |
| T>1 | 32/220 (14.5%) | 8/53 (15.1%) |
| Non-informative | 2/18 (11.1%) | 1/1 (100.0%) |
| N status | ||
| N0 | 12/109 (11.0%) | 1/4 (25.0%) |
| N1 | 7/53 (13.2%) | 1/1 (100.0%) |
| N2 | 1/1 (100.0%) | - |
| Non-informative | 16/127 (12.6%) | 10/59 (16.9%) |
| M status | ||
| M0 | 22/186 (11.8%) | 11/58 (19.0%) |
| M1 | 6/63 (9.5%) | 0/4 (0.0%) |
| Non-informative | 8/41 (19.5%) | 1/2 (50.0%) |
| Tumor grade | ||
| 1–2 | 7/96 (7.3%) | 9/48 (18.8%) |
| 3 | 23/154 (14.9%) | 3/16 (18.8%) |
| Non-informative | 6/40 (15.0%) | - |
| Tumor histology | ||
| Serous adenocarcinoma | 36/250 (14.4%) | 7/41 (17.1%) |
| Mucinous adenocarcinoma | 0/9 (0.0%) | 0/2 (0.0%) |
| Adenocarcinoma, not otherwise specified | 0/16 (0.0%) | 3/11 (27.3%) |
| Other | 0/15 (0.0%) | 2/10 (20.0%) |
*Family history was defined as the presence of breast and/or ovarian cancer in mother or sister.