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. 2009 Apr 9;4(4):e5159. doi: 10.1371/journal.pone.0005159

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) A schematic representation schedule of E2 tablet implantation and MRA monitoring. (B) Chronic E2 treatment completely rescues cerebrovascular deficits in 3.5 month-old male M5R^−/− mice. After MRA, an E2 tablet (0.1 mg / 21 days release) was implanted into the neck of each mouse, followed by MRA testing 3 weeks after the start of E2 administration. (C) The increased NHE1 expression levels in male M5R^−/− mice. Na⁺/H⁺ exchanger isoform 1 (NHE1)is indicated by Red color. The GFAP is indicated by Green color. The site where the choroid plexus between fimbria of hippocampus and ventricle is indicated by arrows. Scale bar; 100 µm.