Fig. 1.
Model of spirochaetal lipoprotein export. The above model is based on what is known about bacterial lipoprotein export and the finding of orthologues of secretory proteins in spirochaetal genomes. The mechanism by which spirochaetal lipoproteins are exported has not been demonstrated experimentally. Abbreviations: A, prolipoprotein (with signal peptide) immediately after secretion; B, subsurface lipoprotein in the outer leaflet of the cytoplasmic membrane; C, subsurface lipoprotein in the inner leaflet of the outer membrane; D, surface-exposed lipoprotein in the outer leaflet of the outer membrane; Lsp, prolipoprotein signal peptidase.