Table III.

Risk of NSCLC associated with polymorphisms in candidate genes, by cigarette smoking, hormone use and race

	Totala		White womenb		White ever smokersb		White non-smokersc		White ever HRTb		White never HRTb
	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
	n = 504 cases, n = 527 controls		n = 389 cases, n = 406 controls		n = 351 cases, n = 196 controls		n = 31 cases, n = 199 controls		n = 233 cases, n = 269 controls		n = 270 cases, n = 258 controls
CYP1A1 Msp1
T/T	1.00		1.00		1.00		1.00		1.00		1.00
T/C and C/C	0.95	0.66–1.36	0.78	0.50–1.22	0.78	0.48–1.27	0.54	0.15–1.89	0.96	0.53–1.16	0.59	0.30–1.16
CYP1A1 Ile462Val
A/A	1.00		1.00		1.00		1.00		1.00		1.00
A/G and G/G	0.77	0.42–1.41	0.57	0.29–1.14	0.58	0.27–1.23	0.78	0.17–3.63	0.83	0.33–2.12	0.36	0.13–1.04
CYP1B1
C/C	1.00		1.00		1.00		1.00		1.00		1.00
C/G and G/G	1.26	0.88–1.81	1.15	0.79–1.68	1.19	0.77–1.82	1.06	0.47–2.39	1.22	0.74–2.04	1.05	0.59–1.86
CYP17
A1/A1	1.00		1.00		1.00		1.00		1.00		1.00
A1/A2 and A2/A2	1.21	0.88–1.65	1.16	0.81–1.67	1.11	0.73–1.68	1.52	0.67–3.46	1.41	0.86–2.30	0.83	0.47–1.46
CYP19A1
<10	1.00		1.00		1.00		1.00		1.00		1.00
10+	0.93	0.67–1.30	1.02	0.70–1.49	1.06	0.69–1.64	0.81	0.37–1.80	0.76	0.46–1.27	1.45	0.82–2.57
NQO1
C/C	1.00		1.00		1.00		1.00		1.00		1.00
C/T and T/T	0.93	0.67–1.28	0.94	0.65–1.38	0.93	0.61–1.43	0.97	0.42–2.25	0.72	0.43–1.20	1.25	0.71–2.20
GSTM1
Present	1.00		1.00		1.00		1.00		1.00		1.00
Null	1.40	1.02–1.91	1.28	0.90–1.83	1.38	0.92–2.07	0.97	0.46–2.08	1.20	0.74–1.94	1.45	0.85–2.48
GSTT1
Present	1.00		1.00		1.00		1.00		1.00		1.00
Null	1.23	0.85–1.78	1.20	0.77–1.85	1.51	0.91–2.53	0.47	0.15–1.46	1.45	0.82–2.54	0.92	0.45–1.87
GSTP1
G/G	1.00		1.00		1.00		1.00		1.00		1.00
A/G and A/A	1.59	1.02–2.47	1.85	1.04–3.27	1.69	0.90–3.16	4.75	0.62–36.57	1.50	0.69–3.28	2.21	0.95–5.16
COMT
G/G	1.00		1.00		1.00		1.00		1.00		1.00
A/G and A/A	1.10	0.78–1.56	1.13	0.73–1.74	1.22	0.74–2.01	0.79	0.34–1.86	1.51	0.85–2.68	0.80	0.41–1.58
XRCC1
A/G and G/G	1.00		1.00		1.00		1.00		1.00		1.00
A/A	1.62	1.01–2.60	1.68	1.01–2.79	2.11	1.13–3.94	0.92	0.29–2.90	1.70	0.82–3.55	1.57	0.76–3.26
			Black womenb		Black ever smokersb		Black non-smokersc		Black ever HRTb		Black never HRTb
			OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
			n = 115 cases, n = 121 controls		n = 102 cases, n = 63 controls		n = 8 cases, n = 53 controls		n = 30 cases, n = 40 controls		n = 85 cases, n = 81 controls
CYP1A1 Msp1
T/T			1.00		1.00		1.00		1.00		1.00
T/C and C/C			1.48	0.78–2.80	1.42	0.68–2.93	1.01	0.18–5.85	0.62	0.18–2.18	1.99	0.88–4.48
CYP1A1 Ile462Val
A/A			1.00		1.00		1.00		1.00		1.00
A/G and G/G			2.95	0.63–13.77	2.80	0.55–14.27	d	d	2.88	0.27–30.64	1.64	0.21–12.58
CYP1B1
C/C			1.00		1.00		1.00		1.00		1.00
C/G and G/G			8.29	0.95–72.28	11.09	1.18–104.25	d	d	d	d	5.95	0.61–58.46
CYP17
A1/A1			1.00		1.00		1.00		1.00		1.00
A1/A2 and A2/A2			1.28	0.69–2.35	1.00	0.50–2.03	2.30	0.40–13.25	2.81	0.79–10.05	1.07	0.50–2.29
CYP19A1
<10			1.00		1.00		1.00		1.00		1.00
10+			0.73	0.36–1.46	0.62	0.28–1.41	1.40	0.29–6.83	0.87	0.24–3.12	0.82	0.34–1.99
NQO1
C/C			1.00		1.00		1.00		1.00		1.00
C/T and T/T			0.90	0.47–1.72	0.94	0.44–2.00	1.36	0.25–7.52	0.49	0.14–1.67	1.29	0.55–3.01
GSTM1
Present			1.00		1.00		1.00		1.00		1.00
Null			1.80	0.92–3.51	1.82	0.81–4.08	2.53	0.55–11.69	1.40	0.39–5.01	1.60	0.69–3.71
GSTT1
Present			1.00		1.00		1.00		1.00		1.00
Null			1.31	0.65–2.65	1.84	0.79–4.28	0.30	0.03–3.24	2.51	0.62–10.19	1.16	0.48–2.79
GSTP1
G/G			1.00		1.00		1.00		1.00		1.00
A/G and A/A			1.25	0.62–2.54	1.17	0.51–2.66	2.28	0.25–20.55	1.18	0.31–4.53	1.45	0.59–3.56
COMT
G/G			1.00		1.00		1.00		1.00		1.00
A/G and A/A			1.07	0.59–1.95	1.13	0.56–2.28	1.02	0.22–4.63	2.00	0.62–6.49	0.83	0.39–1.77
XRCC1
A/G and G/G			1.00		1.00		1.00		1.00		1.00
A/A			1.40	0.35–5.58	4.52	0.48–42.99	d	d	2.24	0.20–24.54	0.92	0.15–5.76

^aAdjusted for race, BMI, age, family history of lung cancer, pack-years of smoking and obstructive lung disease.

^bAdjusted for BMI, age, family history of lung cancer, pack-years of smoking and obstructive lung disease.

^cAdjusted for BMI, age and family history of lung cancer.

^dUnable to calculate due to sample size.