Table 3. Peptides enriched in lung tissue during in vivo selection for lung-homing AAV after four rounds of selection.
| Selection pathway | Peptide a | Charge pattern b |
| 5 minutes circulation | PRSADLA | y+xy-yy |
| PRSADLA | y+xy-yy | |
| VRSAADI | y+yyy-y | |
| PRSTSDP | y+xxx-y | |
| PRSTSDP | y+xxx-y | |
| PRSVDLS | y+xy-yx | |
| RGDLGLS | +y-yyyx | |
| 2 days circulation | PRSADLA | y+xy-yy |
| PRSADLA | y+xy-yy | |
| PRSADLA | y+xy-yy | |
| VRSAADI | y+yyy-y | |
| PRSTSDP | y+xxx-y | |
| PRSVDLS | y+xy-yx | |
| PRSVDLS | y+xy-yx | |
| PASADLA | yyxy-yy | |
| Consensus motif | P R S A D (D/L) (A/S) |
a
single letter code; shared amino acid patterns are highlighted in red letters
b
charge pattern of amino acid side chains: +, positively charged; − negatively charged; x, uncharged polar; y, nonpolar.